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KMID : 1009020190170030409
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Clinical Psychopharmacology and Neuroscience
2019 Volume.17 No. 3 p.409 ~ p.414
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The Efficacy of Miniaturized Repetitive Transcranial Magnetic Stimulation in Patients with Depression
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Lee Sang-Min
Jang Kuk-In
Yoon Se-Jin
Chae Jeong-Ho
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Abstract
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Objective: The present study aimed to evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) at a high frequency using a miniaturized device compared to standard rTMS and sham rTMS for the treatment of depression.
Methods: Fifty-four patients with depression were randomly assigned to either 15 days of miniaturized, standard, or sham rTMS. The stimulation consisted of 60 trains of 5 seconds at 10 Hz for 30 minutes. Clinical measures were assessed at baseline and on the final day of the stimulation.
Results: A repeated-measures analysis of variance revealed a significant main effect of time and a time by group interaction on Hamilton Rating Scale for Depression scores. There were no significant correlations between individual motor thresholds and changes of clinical outcomes. Our results revealed a significant reduction in the Hamilton Rating Scale for Depression in the miniaturized and standard groups compared to the sham group.
Conclusion: The antidepressant utility of miniaturized rTMS using subthreshold stimulation was comparable to that of standard stimulation.
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KEYWORD
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Depression, Transcranial magnetic stimulation, Antidepressants
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